Application

27-hydroxycholesterol has been used: to test its inhibitory effect on hepatic lipid accumulationas liver X receptor (LXR) ligand in breast cancer cell linesas a control in liquid chromatography with tandem mass spectrometry (LC-MS-MS) for the quantitation of 25-OHC in jejunum samples

Biochem/physiol Actions

27-hydroxycholesterol (27-HC) is a weak liver X receptor (LXR) agonist and a selective estrogen receptor modulator (SERM). Elevated levels of 27-HC is observed in hypercholesterolemia. 27-HC is implicated in breast cancer tumor and glioblastoma progression. 27-HC may help in treating non-alcoholic steatohepatitis. Elevated levels of 27-HC is associated with atherosclerotic lesions.

General description

27-hydroxycholesterol (27-HC) is synthesized from cholesterol by the action of sterol 27-hydroxylase in liver. It is an abundant oxysterol in the circulation ranging from 0.15 to 0.73 μM. 27-HC serves as a substrate for bile synthesis.

Packaging

5 mL Amber Glass Screw Cap Vial (700021P-25mg)

5 mL Amber Glass Screw Cap Vial (700021P-5mg)

5 mL Amber Glass Screw Cap Vial (700021P-1mg)