Application

XPhos may be used as a ligand in the following reactions:Preparation of functionalized benzylic sulfones via palladium-catalyzed Negishi cross-coupling between alkyl sulfones and aryl halides.Along with pre-milled palladium(II) acetate as a pre-catalyst for the Stille cross-coupling of aryl chlorides with tributylarylstannanes to form the corresponding biaryl compounds.Along with platinum chloride to catalyze the hydrosilylation of terminal arylalkynes with silanes to form functionalized β-(E)-vinylsilanes.

Preferred ligand for greener Sonogashira coupling in TPGS-750-M.On the Way Towards Greener Transition-Metal-Catalyzed Processes as Quantified by E Factors

Preferred ligand for greener Sonogashira coupling in TPGS-750-M.

Ligand for increased scope of Pd-catalyzed amination and amidation via arene sulfonates, aryl halides.

Ligand used in a Pd-catalyzed Suzuki coupling leading to C-15 analogs of vindoline.Direct annulation of 2-haloanilines to indoles and tryptophans catalyzed by Pd. Synthesis of regioregular polythiophenes.

General description

XPhos [2-Dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl] is an air-stable electron-rich biaryl monophosphine ligand² developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.

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Legal Information

Usage subject to US Patent 7,223,879

Usage subject to US Patents 6307087 and 6395916.

Packaging

1, 5, 25, 100, 500 g in glass bottle