Application
XPhos may be used as a ligand in the following reactions:Preparation of functionalized benzylic sulfones via palladium-catalyzed Negishi cross-coupling between alkyl sulfones and aryl halides.Along with pre-milled palladium(II) acetate as a pre-catalyst for the Stille cross-coupling of aryl chlorides with tributylarylstannanes to form the corresponding biaryl compounds.Along with platinum chloride to catalyze the hydrosilylation of terminal arylalkynes with silanes to form functionalized β-(E)-vinylsilanes.
Preferred ligand for greener Sonogashira coupling in TPGS-750-M.On the Way Towards Greener Transition-Metal-Catalyzed Processes as Quantified by E Factors
Preferred ligand for greener Sonogashira coupling in TPGS-750-M.
Ligand for increased scope of Pd-catalyzed amination and amidation via arene sulfonates, aryl halides.
Ligand used in a Pd-catalyzed Suzuki coupling leading to C-15 analogs of vindoline.Direct annulation of 2-haloanilines to indoles and tryptophans catalyzed by Pd. Synthesis of regioregular polythiophenes.
General description
XPhos [2-Dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl] is an air-stable electron-rich biaryl monophosphine ligand2 developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.
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Legal Information
Usage subject to US Patent 7,223,879
Usage subject to US Patents 6307087 and 6395916.
Packaging
1, 5, 25, 100, 500 g in glass bottle
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