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Bafilomycin A1 from Streptomyces griseus, >=90% (HPLC)

Code: B1793-2UG D2-231

Application

Bafilomycin A1 has been used:as an autophagy inhibitor to study its effects on hepatic steatosis in human hepatocytesas a vacuolar-type H+ -ATPase inhi...


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€121.12 2UG
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Application

Bafilomycin A1 has been used:as an autophagy inhibitor to study its effects on hepatic steatosis in human hepatocytesas a vacuolar-type H+ -ATPase inhibitor to study its effects on the cell viability, percentage of PI-positive cells, and glucose-stimulated insulin secretion (GSIS) in mice INS-1 cellsas a vacuolar-type H+ -ATPase inhibitor to study its effects on tau degradation in human SH-SY5Y cells

Biochem/physiol Actions

A specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms.

Bafilomycin A1 inhibits autophagosome-lysosome fusion and autolysosome acidification, the steps involved in the autophagic process that is required for maintaining functional autophagic flux and cellular homeostasis.

General description

Chemical structure: macrolide

Packaging

2, 10 µg in serum bottle

antibiotic activity spectrumfungi
assay≥90% (HPLC)
formfilm
InChI keyXDHNQDDQEHDUTM-JQWOJBOSSA-N
InChI1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1
mode of actionenzyme | inhibits, DNA synthesis | interferes
Quality Level300
SMILES stringCO[C@H]1C=CC=C(C)C[C@H](C)[C@H](O)[C@H](C)C=C(C)C=C(OC)C(=O)OC1[C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](O)[C@H](C)[C@H](O2)C(C)C
storage temp.−20°C
Code
Description
Unit Size
List Price
Qty
B1793-10UG
Bafilomycin A1 from Streptomyces griseus, >=90% (HPLC)

Unit:10UG
List Price: €356.11
Source:List Price
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Cas Number88899-55-2
This product has met the following criteria: